Oria Bioscience

Focus Areas

Exploring the subcellular world of organelles.
Uncover their role across therapeutic areas and research applications, from discovery to clinical translation.

Therapeutic Areas

Organelles are central to the molecular mechanisms driving some of the most prevalent and complex human diseases. From impaired lysosomal clearance in neurodegeneration to mitochondrial stress in cancer and

metabolic disorders, subcellular dysfunction is a shared hallmark across therapeutic areas. Understanding these mechanisms at the organelle level opens new avenues for target identification and drug intervention.

Application Areas

Whether you are an academic researcher, part of a CRO, or developing a new drug, our purified organelle preparations support a broad range of research applications. From electrophysiology and enzyme activity

assays to high-throughput screening and biomarker discovery, our preparations are designed to deliver native-state biology wherever you need subcellular resolution.

KEY PARTNERS •

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Breaking barriers in lysosomal electrophysiology: Automated solutions for ion channel analysis

Breaking barriers in lysosomal electrophysiology: Automated solutions for ion channel analysis

with Sophion Bioscience

Automated Patch Clamp (APC) of lysosomal ion channels was achieved using enlarged lysosomes (LYSO-Prep™, Oria Biosci ence), enabling measurement of ion channel activity such as TRPML1. Lysosomes were successfully captured on two Sophion systems, with success rates of 69.9 ± 3.2% on the QPatch® 48 and 74.6 ± 2.6% on the Qube® 384. The lysosomal recordings showed stable seals and robust TRPML1 current responses…

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LYSO-Prep™ for organellar electrophysiology: A new tool for high throughput measurement of lysosomal TRPML1 channels using the SyncroPatch 384, SURFE2R N1 and SURFE2R 96SE

LYSO-Prep™ for organellar electrophysiology: A new tool for high throughput measurement of lysosomal TRPML1 channels using the SyncroPatch 384, SURFE2R N1 and SURFE2R 96SE

with Nanion Technologies

The gold standard to functionally characterize lysosomal ion channels remains manual patch clamp recordings of enlarged individual lysosomes isolated from individual cells1. This technique is time-consuming and technically challenging, but other electrophysiological techniques are beginning to overcome these challenges, resulting in higher throughput characterization of isolated lysosomes…

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New frontier: Investigating regulation of lysosomal ion channels at elevated temperatures in the native system

New frontier: Investigating regulation of lysosomal ion channels at elevated temperatures in the native system

with Nanion Technologies

Ion channel activity is modulated by various stimuli including voltage, pH, lipids or neurotransmitters that turn various inputs into electrical signals. In addition, the activity can also be modulated by temperature with the example of the transient receptor potential (TRP) family of ion channels that show a remarkably high sensitivity to changes in temperature and mediate temperature-sensation in animals.

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